Banca de DEFESA: WESLEY PIMENTA CÂNDIDO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : WESLEY PIMENTA CÂNDIDO
DATE: 28/03/2025
TIME: 17:00
LOCAL: Sala do PGCA
TITLE:

EVALUATIONOFTHEPHYTOCHEMICALANDTOXICOLOGICALPROPERTIESOFTHE
HYDROALCOHOLICEXTRACTFROMTHELEAVESANDSTEMOFCostusspiralis
(Jacq.)RoscoeINMICROCRUSTACEANSANDNEMATODES

KEY WORDS:

 medicinal plants; nematodes; aquatic microcrustaceans; lethality; phytochemical compounds

PAGES: 64
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Costus spiralis (Jacq.) Roscoe is a medicinal plant from the Costaceae family, widely used in Brazilian folk medicine, especially by indigenous communities in the Amazon, to treat conditions such as inflammations, renal diseases, and gastrointestinal disorders. This study aimed to evaluate the phytochemical and toxicological profile of the hydroalcoholic extract of C. spiralis leaves and stems on the nematodes Turbatrix aceti and Panagrellus redivivus, and on the microcrustaceans Artemia salina, Daphnia magna, and Dendrocephalus brasiliensis. The hydroalcoholic extract of C. spiralis leaves and stems was obtained by extracting dried plant tissues, followed by phytochemical analysis. For the toxicity assays, two types of organisms were used: nematodes (T. aceti and P. redivivus) and microcrustaceans (A. salina, D. brasiliensis, and D. magna). The assays were performed in triplicate, calculating the LC₅₀ values, which indicate the lethal concentration of the extract. During the tests, the organisms were exposed to the extract for different periods (24 and 48 hours), and mortality was recorded for toxicity evaluation. The results showed that the toxicity of the C. spiralis extract is dose-dependent and cumulative over time. Mortality increased as the extract concentration and exposure time increased. For the nematodes, a direct relationship between extract concentration and mortality was observed, with a strong statistical correlation (high R²). Among the microcrustaceans, A. salina and D. brasiliensis were the most sensitive species, showing higher mortality after 48 hours of exposure. The phytochemical analysis revealed the presence of compounds such as flavonoids, terpenes, and saponins but did not detect alkaloids or coumarins. The obtained data indicate that the C. spiralis extract has considerable toxicity, with more pronounced effects after 48 hours of exposure. The response of the test organisms was dose-dependent, highlighting the need for further research on the mechanisms of action of the bioactive compounds present in the plant. Finally, continued investigation is essential to ensure the safety and efficacy of the plant in phytotherapeutic treatments.

COMMITTEE MEMBERS:
Externo à Instituição - FRANCISCO CARLOS DA SILVA - São Lucas
Interno - 1846780 - SANDRO DE VARGAS SCHONS
Presidente - 1212049 - SYLVIANE BECK RIBEIRO