Banca de DEFESA: LORRAYNIE OLIVEIRA ALVES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LORRAYNIE OLIVEIRA ALVES
DATE: 28/03/2025
TIME: 14:00
LOCAL: Sala do PGCA
TITLE:

PHYTOCHEMICAL PROSPECTING, CYTOTOXICITY AND ACTIVITY
ANTIBACTERIAL OF HYDROALCOHOLIC AND METHANOLIC EXTRACTS OF

LEAVES OF Sterculia striata A. St.-Hil. & Naudin (Chicha)

KEY WORDS:

Chichá. Secondary metabolites. Artemia salina. Disk diffusion. Well diffusion.

PAGES: 54
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

This Master's Dissertation follows the classical structure, beginning with a Theoretical
Framework followed by a research article. The focus of this study was the leaves of Sterculia
striata. Sterculia striata A. St.-Hil. & Naudin, commonly known as chicha, is a plant species
traditionally used for various therapeutic purposes. However, scientific literature lacks studies
evaluating its pharmacological properties, particularly those of its leaves. Thus, this study
aimed to identify the secondary metabolites present in the hydroalcoholic and methanolic
extracts of S. striata leaves, assess their cytotoxicity through the Artemia salina bioassay, and
investigate their antibacterial activity against Escherichia coli (ATCC 25922), Salmonella
enteritidis (ATCC 13076), Staphylococcus aureus (ATCC 25923), and Pseudomonas
aeruginosa (ATCC 27853). Phytochemical analysis revealed the presence of flavonoids,
coumarins, tannins, saponins, and alkaloids, with variations between extracts. In the
cytotoxicity assay, the Lethal Concentration 50% (LC50) was approximately 1.15 mg/dL,
classifying the extracts as highly toxic to A. salina. In the antibacterial tests, no inhibition of
bacterial growth was observed. The findings suggest that although the extracts contain bioactive
compounds, their toxicity should be considered, and their antimicrobial activity may depend on
chemical modifications or interactions with other substances. Therefore, further studies are
essential to deepen the understanding of the therapeutic potential of this species.

COMMITTEE MEMBERS:
Externo à Instituição - FRANCISCO CARLOS DA SILVA
Externa à Instituição - NATÁLIA MALAVASI VALLEJO
Presidente - 1212049 - SYLVIANE BECK RIBEIRO