Banca de DEFESA: VALÉRIA BASTOS DE ARAÚJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : VALÉRIA BASTOS DE ARAÚJO
DATE: 27/03/2024
TIME: 14:00
LOCAL: LICBIO/UNIR
TITLE:

Medicinal plants. resistance. bioactives. gas chromatography. mass spectrometry.

KEY WORDS:

Medicinal plants. resistance. bioactives. gas chromatography. mass spectrometry.

PAGES: 43
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Currently, existing antimalarials have, without exception, some limitation, be it the resistance of Plasmodium falciparum to chloroquine and other quinoline derivatives, or the drug combinations of artemisinin and its derivatives, which have a high production cost and make their use in developing regions difficult making its prophylactic and therapeutic arsenal very restricted. The resistance of parasites to antimalarial drugs is a
global problem requiring constant research into more potent drugs, and plants, with their enormous production of secondary metabolites, are a source of bioactive compounds. Since the 1970s, the World Health Organization has recognized the importance of popular knowledge as an available source of new medicines, often the traditional use of plants represents the only form of treatment, especially for patients in the poorest regions. The main antimalarials on the market are of natural origin such as artemisinin and quinine, therefore, given the importance and need to find new treatments given the potential uses of Morinda citrifolia, this present study seeks to determine the antimalarial activity of its essential oil (OE). Morinda citrifolia, popularly known as noni, is an easily accessible plant, with fruit production throughout the year, facilitating the collection of fruits for extraction of their OE, in addition to adapting well to biotic and abiotic stress. To determine antioxidant activity (AA), the DPPH method was used, % AA was found with averages of 44.78 to 48.99, for the initial concentrations. Gas chromatography coupled to mass spectrometry was used to carry out quantitative analyses, and 26 compounds were identified in two samples of M. citrifolia essential oil through comparative analysis of the mass spectra obtained with those available in the NIST library, being the major compounds octanoic acid and methylchavicol were found. Octanoic acid has been used as an attractant to capture Anopheles, which opens up a range of possibilities not only for in vitro studies, but also for the production of traps.

COMMITTEE MEMBERS:
Presidente - ***.337.517-** - GEISA PAULINO CAPRINI EVARISTO - FIOCRUZ
Interno - 1530806 - ALEXANDRE DE ALMEIDA E SILVA
Interna - ***.785.002-** - MAISA DA SILVA ARAÚJO - UNIR
Externo ao Programa - ***.574.687-** - JOSEPH ALBERT MEDEIROS EVARISTO - UENF
Externa ao Programa - 2245719 - SHEILA BARRETO GUTERRES - UNIR